Meet Our Team
Associate Professor
Dr. Leslie Than Thian Lung
Principle Investigator
Dr. Chew Shu Yih
Postdoctoral Research Fellow
Mohd Yusop Radiman
Senior Medical Lab Technologist
Premmala Rangasamy
PhD Candidate
Low Cheng Yee
PhD Candidate
Wallace Chee Jeng Yang
MSc Candidate
Angela Boahen
MSc Candidate
Loke Yi-Linn
MSc Candidate
Theysshana Visuvanathan
MSc Candidate
Ang Li Hui
MSc Candidate
Siti Nor Hikmah Abdul Rasid
MSc Candidate
Subatrra Nair Balakrishnan
MSc Candidate

Haizat Bin Yamang

PhD Candidate
Dr. Ng Tzu Shan
Alumni
Choo Sulin
Alumni
Hadiza Meleh Umar
Alumni
Nurhairulamri Kosnan
Alumni
Muhammad Zaim Bin Mohd Shairy
Alumni
Dr. Hassan Yahaya
Alumni
Mission
Mycology Lab performs highly innovative medical mycological and microbiological research that contributes to the understanding of complexity between microorganisms. Our goal is to promote the in-depth exploration of medically-important fungi and probiotic discovery.
Research
Established in 2011 by an aspiring scientist Associate Professor Dr. Leslie Than Thian Lung, Mycology Lab currently consists of four research groups: Candida Research Group, Probiotics Research Group, UTIs Research Group and Leptospirosis Research Group. The Mycology Lab focuses on innovative research in medical mycology, particularly in diagnosis and pathogenesis of Candida species. We are also centred on the discovery and development of probiotics intended for improving human health. In addition, our group is also involved in early diagnostic and prognostic biomarkers discovery for leptospirosis using multi-omics framework.
Research Groups
1
Candida Research Group
Group members:
Dr. Chew Shu Yih, Dr. Ng Tzu Shan, Dr. Hassan Yahaya, Wallace Chee Jeng Yang, Subatrra Nair Balakrishnan, Haizat Bin Yamang
2
Probiotics Research Group
Group members:
Dr. Chew Shu Yih, Premmala Rangasamy, Choo Sulin, Hadiza Umar Meleh, Wallace Chee Jeng Yang, Loke Yi-Linn, Angela Boahen, Ang Li Hui
3
UTIs Research Group
Group members:
Theysshana Visuvanathan, Siti Nor Hikmah Abdul Rasid
4
Leptospirosis Research Group
Group members:
Low Cheng Yee, Nurhairulamri Kosnan, Muhammad Zaim Mohd Shairy
Selected Publications

Yahaya, H., Chew, S.Y., Than, L.T.L. (2021). Candida glabrata: pathogenicity and resistance mechanisms for adaptation and survival. Journal of Fungi 7: 667.


Yahaya, H. and Than, L.T.L. (2021). Modified and improved DNA extraction method for molecular detection of Candida species from positive blood culture bottles. Jundishapur Journal of Microbiology 14: e106146.


Chew, S.Y., Brown, A., Lau, B.Y.C., Cheah, Y.K., Ho, K.L., Sandai, D., Yahaya, H., Than, L.T.L. (2021). Transcriptomic and proteomic profiling revealed reprogramming of carbon metabolism in acetate-grown human pathogen Candida glabrata. Journal of Biomedical Science 28:1.


Chee, W.J.Y., Chew, S.Y., Than, L.T.L. (2020). Vaginal microbiota and the potential of Lactobacillus derivatives in maintaining vaginal health. Microbial Cell Factories 19: 203.


Yahaya, H., Than, L.T.L. (2020). Loop-mediated isothermal amplification (LAMP): comparative advances over conventional PCR and other molecular techniques. Annual Research and Review in Biology 35: 33-44.


Umar Meleh, H., Choo, S., Mohd Desa, M.N., Chew, S.Y., Rangasamy, P., Hassan, H., Than, L.T.L. (2020). Isolation and safety characterisation of lactobacilli strains with antimicrobial properties as potential probiotics for human

use. LWT - Food Science and Technology 131: 109796.


Fish-Low, C.Y.,Balami, A.D., Than, L.T.L.,Ling, K.H., Mohd Taib, N., Md Shah, A., Sekawi, Z. (2020). Hypocalcemia, hypochloremia, and eosinopenia as clinical predictors of leptospirosis: A retrospective study. Journal of Infection and Public Health 13: 216-220.


Fish-Low, C.Y., Than, L.T.L., Ling, K.H., Lin, Q., Sekawi, Z. (2020). Plasma proteome profiling reveals differentially expressed lipopolysaccharide-binding protein among leptospirosis patients. Journal of Microbiology, Immunology and Infection 53: 157-162.


Chew, S.Y., Chee, W.J.Y., Than, L.T.L. (2019). Glyoxylate cycle and alternative carbon metabolism as the metabolic adaptation strategy of Candida glabrata: perspectives from Candida albicans and Saccharomyces cerevisiae. Journal of Biomedical Science 26: 52.


Chew, S.Y., Ho, K.L., Cheah, Y.K., Ng, T.S., Sandai, D., Brown, A., Than, L.T.L. (2019). Glyoxylate cycle gene ICL1 is essential for the metabolic flexibility and pathogenicity of Candida glabrata. Scientific Reports 9: 2843.


Chew, S.Y., Ho, K.L., Cheah, Y.K., Sandai, D., Brown, A., Than, L.T.L. (2019). Physiologically relevant alternative carbon sources modulate biofilm formation, cell wall architecture, and the stress and antifungal resistance of Candida glabrata. International Journal of Molecular Sciences 20: E3172.


Choo, S., Chew, B.H., Mohd Jamil, A.A., Chew, S.Y., Umar Meleh, H., Than, L.T.L. (2019). Characterisation of the probiotic qualities exhibited by lactobacilli strains isolated from the anogenital tract. Malaysian Journal of Medicine and Health Sciences 15(1): 37 – 45.


Yahaya, H., Abdullahi, S.A., Than, L.T.L. (2018). Candida albicans interdigital foot infection: A case report highlighting the importance of antifungal susceptibility testing. African Journal of Microbiology Research 12: 889-896.


Ng, T.S., Chew, S.Y., Rangasamy, P., Mohd Desa, M.N., Sandai, D., Chong, P.P., Than, L.T.L. (2016). SNF3 as high affinity glucose sensor and its function in supporting the viability of Candida glabrata under glucose-limited environment. Frontiers in Microbiology 6: 1334.


Ng, T.S., Desa, M.N.M., Sandai, D., Chong, P.P., Than, L.T.L. (2016). Growth, biofilm formation, antifungal susceptibility and oxidative stress resistance of Candida glabrata are affected by different glucose concentrations. Infection, Genetics and Evolution 40: 331-338.


Chew, S.Y. and Than, L.T.L. (2016). Vulvovaginal candidosis: Contemporary challenges and the future of prophylactic and therapeutic approaches. Mycoses 59(5): 262-273.


Ng, T.S., Desa, M.N.M., Sandai, D., Chong, P.P., Than, L.T.L. (2015). Phylogenetic and transcripts profiling of glucose sensing related genes in Candida glabrata. Jundishapur Journal of Microbiology 8: e25177.


Chew, S.Y., Cheah, Y.K., Seow, H.F., Sandai, D., Than, L.T.L. (2015). In vitro modulation of probiotic bacteria on the biofilm of Candida glabrata. Anaerobe 34: 132-138.


Chew, S.Y., Cheah, Y.K., Seow, H.F., Sandai, D., Than, L.T.L. (2015). Probiotic Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 exhibit strong antifungal effects against vulvovaginal candidiasis-causing Candida glabrata isolates. Journal of Applied Microbiology 118(5): 1180-1190.





Vacancies
  • No vacancy at the moment

Collaborations
Mycology Lab not only focuses on research but also ventures into establishing collaboration with other local and overseas academic institutions, government agencies and industrial organisations. Among the organisations include University of Aberdeen (UK), University of Exeter (UK), Chr. Hansen (Denmark), Malaysia Palm Oil Board (MPOB), Cargill Malaysia, ISF, Mewah Oils, Revongen, and B-Crobes.
Industrial Engagement with Cargill Malaysia
Research Collaboration with Professor Alistair Brown from MRC Centre for Medical Mycology, University of Exeter.
More...
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Contact Us
Phone:+603 9769 2373
E-mail: leslie@upm.edu.my/ mycologylabupm@gmail.com
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